Fluoroquinolones and Quinolones
Examples:-
Ciprofloxacin, nalidixic acid, norfloxacin and ofloxacin.
Comments:-
These drugs are a newer type of anti-infective. Their action is to interfere
with DNA replication by inhibiting an enzyme complex called DNA gyrase.
This can also affect mammalian cell replication.
Their chemical structure is of a quinolone base with a
fluorine side chain. Quinine is also a quinolone, but it does not have
clinically useful antibacterial properties. Nalidixic acid is a quinolone
without a fluoride side chain.
Development of resistance to these drugs has been suprisingly high.
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