Chloramphenicol
Comments:-
An excellent broad spectrum antibiotic that is still used for eye
and ear infections. It is generally not used widely sytemically (specially in children)
due to substantial risks for bone marrow degeneration leading to aplastic
anaemia or bone marrow hypoplasia. Some physicians and institutions have a policy
of not using it.
extended use over 40 years has indicated that an extremely small number of individuals have developed aplastic anaemia
following extended (and largely unsupervised) use of chloramphenicol eye products.
Protein synthesis inhibitor drugs are all broad spectrum and
providing resistance has not developed, they are affective
against the most common Gram positive and Gram negative organisms.
Chloramphenicol is not effective against pseudomonas aeriginosa
and serratia marcescens.
Chloramphenicol should be stored between 2°C and 8°C.
|