Notes to accompany City University 3rd year undergraduate Clinical Practice course lecture
Dr Simon Barnard PhD BSc FCOptom FAAO DCLP
Introduction
Optometrists in the UK are responsible not only for detecting ocular disease
but also systemic disease with ocular manifestation. In optometric practice,
the practitioner will frequently observe the effects of vascular disease.
This may be local to the eye or may affect the broader visual system.
Thus a full range of signs may be diagnosed from visual field defects, paretic squints,
gaze palsies and nystagmus due to stroke or aneurysms within the brain, to specific
retinal haemorrhages secondary to a wide range of disease processes.
Vascular hypertension
- Prevalence. Approx 10% to 15% of UK population
- One of the commonest contributing causes of death or morbid events
- Fundus signs may be graded e.g. Keith, Wagener & Barker (1939)
- Grade 1 Narrowing of the arterioles (general or focal)
- Grade 2 More marked than grade 1
- Grade 3 Grade 2 + cotton wool spots + haemorrhages (often
superficial flame shaped
- Grade 4 Grade 3 + papilloedema
- Aetiology.
Cause of primary or essential hypertension unknown.
Hereditary component. Causes of acute secondary grade 4 hypertension include phaeochromocytoma
- Case finding - fundus examination + sphygmomanometry + family history
- Sphygmomanometric criteria. Refer one reading of diastolic > 110 mm Hg otherwise 2 or more readings of :
Guideline upper levels of blood pressure
Age (years)BP (mm Hg)
18 - 44 140/90
45 - 64 150/90
> 64 160/95
- Chronic hypertension è arteriosclerosis
Arteriosclerosis
- Atheroma or atherosclerosis
- Common degeneration of intima of arteries.
- Hyaline è cholesterol + foam cells è plaques è obstruction
- Can occur in retinal arterioles
- Plaques may be observed in larger vessels
- Involutionary sclerosis
- Replacement fibrosis involving the media of the arteries. Associated with advancing age.
- Almost universal after age 60 years
- Arteriosclerosis associated with vascular hypertension
- Hypertension è hypertonus of media è
hyperplasia (increase in cell numbers)and hypertrophy
(increase in cell size) of media (especially in younger patients) + new elastic fibres
- If acute and overwhelming è cellular necrosis in artery wall
ècirculatory breakdown
- If chronic then hyperplasia is followed by reduction in number of cells
with corresponding laying down of collagen è acellular fibrous vessel wall
- "Corkscrew" appearance of arterioles in macular region
- "Copper wire" = thickening and hyaline degeneration
"Silver wire" = entire vessel is reflecting light
Irregular reflexes
Vessel sheathing. First appears at vessel crossings. May lead to "pipe stem"
- A/V crossing changes:
- concealment of vein
- deflection (Salus' sign) with humping, depression, or deflection
- apparent nipping & tapering (Gunn's sign)
- banking
- Fundus arteriosclerotic signs may be graded e.g. Keith, Wagener & Barker (1939)
- Grade 1 Mild changes in vascular reflexes including widening of reflex and concealment of vein
- Grade 2 Changes in vascular reflex + sclerosis at a/v crossings
- Grade 3 Grade 2 + copper wiring + banking
- Grade 4 Grade 3 + silver wiring. Predisposition to vein occlusion
- Refer for cardiovascular examination including serum cholesterol levels (HDL/LDL)
Arteritis (e.g. temporal or cranial)
- Inflammation of larger arteries usually carotid and often temporal branch but can be systemic
- 24 cases/100,000 > 55 years; female > male; familial predisposition
- Unknown aetiology. ? cell-mediated immune response
- Fever, anaemia, weight loss, sweating, arthralgia
- Symptoms continuous or intermittent and last weeks/months
- Temporal arteritis è headaches, tender scalp, nodular and sensitive temporal artery, claudication on chewing
- Ischaemic optic neuropathy, amaurosis fugax è may lead to permanent visual loss
- Other signs: peripheral claudication, CVA
- Diagnosis from signs, symptoms, temporal artery biopsy. High ESR.
- Excellent response to systemic steroids; Prednisone 80-100 mg/day è 10 mg/day maintenance
Retinal vaso-occlusive disease
- Branch vein occlusion(BRVO)
- strong association with systemic disease
- occurs most frequently at a/v crossings
- Non-ischaemic BRVO è dot-blot haemorrhages and lipid
Ischaemic BRVO è as above + cotton-wool spots and flame-shaped haemorrhages
- Collaterals may form to drain affected area ( NB this is not neovascularisation)
and 25% è neovascularisation of disc or retina
- visual field defect crosses horizontal raphe as oedema spreads
- Check BP and carotid auscultation. Refer for evaluation of lipids, glucose, blood counts and others.
- Fluorescein angiography indicated if macular threatened
- Follow-up for neovascularisation
- Central retinal vein occlusion (CRVO)
- Strong association with systemic disease
- May be associated with localised optic nerve compression
- Occlusion occurs at lamina cribosa
- More likely to occur if artery and vein are juxtapositioned
- Non-ischaemic CRVO è dot/blot haemorrhages to periphery , macular oedema, dilated tortuous veins, choked disc; minimal threat for neovascular glaucoma
- Ischaemic CRVO è signs as above + cotton-wool spots and flame- shaped haemorrhages; 60% chance of neovascular glaucoma
- Rule out raised IOP as cause
- Refer for medical and ophthalmological evaluation
- Possible anticoagulation drugs
- Possible pan-retinal photocoagulation
- Branch retinal artery occlusion (BRAO)
- Strong association with systemic disease especially internal carotid and cardiovascular disease
- Secondary to embolus trapped in retinal artery
- Embolus usually lodges at a bifurcation
- è total anoxia in the region of arteriole è white retina
- May have associated cotton-wool spots
Attempt to dislodge embolus by massage and refer urgently
- Systemic evaluation
- Central retinal artery occlusion (CRAO)
- Strong association with systemic disease especially internal carotid and cardiovascular disease
- Sudden (seconds) painless loss of vision
- Often embolus at lamina cribosa
- Narrowing of arteries , haziness of retinal tissues due to anoxia
- Fragmentation appearance to venular blood
- "Cherry red spot" (choroidal supply) at macular
- ? Cilioretinal artery è small area of residual centrocaecal field
- Urgently attempt dislodging embolus by massage and refer urgently to a Hospital Eye Casualty Department
- ? Paracentesis
- Systemic evaluation
Diabetes mellitus
- May be considered as a capillary vascular disease
- Background retinopathy (deep dot haemorrhages, lipid) è pre- proliferative (venous beading, retinal ischaemia, cotton wool spots, IRMA) è proliferative retinopathy (neovascularisation of venules into sub-hylaoid space) è haemorrhaging into vitreous, fibrosis and retinal detachment. Rubeosis iridis.
- Refer any changes within one disc diameter of fovea, pre-proliferative or proliferative retinopathies for ophthalmological evaluation. Photocoagulation.
- Formal report to GP (UK law) following examination of diabetic
- Report to GP/Diabetologist any changes in background retinopathy - treatment regime may need fine tuning
Radiation retinopathy
- Usually occurs 3 months to 3 years after x-ray irradiation near orbital region
- Microaneurysms, ptelangiactasia, haemorrhages, cotton-wool spots, exudates, optic disc oedema, RPE changes, retinal and iris neovascularisation
- Photocoagulation management similar to diabetes
Retinal periphlebitis (Eales' disease)
- Healthy men 20 - 40 years
- May be bilateral
- Perivasculitis, occasional anterior uveitis, vitritis, peripheral neovascularisation
- Rule out systemic disease e.g. tuberculosis
- Photocoagulation
Sickle-cell retinopathy
- Normal population has haemoglobin A
- Sickle-cell patient have abnormal haemoglobin
- Considerably more common in blacks
- Retinopathy results from alteration of retinal circulation
- Intra-retinal haemorrhages, RPE disturbances, venous tortuosity, neovascularisation, vitreous haemorrhage
- Neovascularisation may benefit from photocoagulation
Retinopathy of prematurity (ROP)
- Risk factors include : prematurity < 36 weeks, under 4lb 6 oz, supplemental oxygen
- The last area of retina to be vascularised is the temporal periphery. ROP is an alteration to this development
- Distinct demarcation line between vascular and avascular retina develops into a ridge.
- May lead to neovascularisation and retinal detachment
Prophylactic cryotherapy
Behçet's disease
- Systemic occlusive vasculitis
- Immune complex disorder
- Young adults 18 - 40 years; Japan & Mediterranean
- Genital and oral ulcers, dermatological problems, GI & CNS involvement
- Recurrent uveitis
- Peripheral retinal vasculitis è rubeosis iridis, glaucoma, cataract, retinal neovascularisation, retinal detachment
- Steroids, photocoagulation
Angiomatosis retinae
- Benign capillary hemangioma
- May be associated with the phakomatosis, von Hippel-Lindau disease
- 50% bilateral
- Appearance of very tortuous vessels feeding orange tumour
- Genetic predisposition
- Genetic counselling
- Possible photocoagulation
Retinal ptelangiectasia (Coat's disease)
- Ptelangiectasia è exudative retinopathy
- Usually unilateral and in males < 20 years
- No genetic association
- No systemic association
- Irregular dilatation of retinal vessels may
è progress to intra and sub retinal exudation
- Possible photocoagulation
MCQs
In order to obtain the greatest benefit from these notes
- read through them carefully
- attempt the MCQs
- click either line a,b,c or d to obtain answer.
- if incorrect or not sure, read through the reference.
Answers 1a 2c 3d 4c 5d 6d